Another likely pathogenic variant p.V377I rs28934897 in the MVK gene associated with hyper-IgD syndrome (OMIM: 260920) was significantly enriched in the Qatar Arab subpopulation with AF 0.8% compared to the global AF i.e., absent in 1000 genomes, and ~0.15% in Esp6500, gnomAD V2, and gnomAD V3. The gene discussed is MVK; the disease is atrial fibrillation.