Another likely pathogenic variant p.N852S in the NOD2 gene associated with Blau syndrome (OMIM number 186580), Crohn’s disease (OMIM number 266600), and Yao syndrome (OMIM number 617321) was significantly enriched in the GME population and its Northeast Africa (NEA) subpopulation in comparison to the global control population. The gene discussed is NOD2; the disease is Yao syndrome.