TNFSF14 and neoplasm: In the former cases, B cells are hypothesized to serve as intrinsic immunoregulatory cells or facilitators of Treg recruitment/development/function (82–85), while in the latter situation, B cells are believed to serve as supportive antigen-presenting cells and/or producers of pro-TLS cytokines (i.e. LIGHT) and therapeutic anti-tumor antibodies (19, 78, 88–93).