NRG4 and central nervous system cancer: The results showed that NRG1 (p=0.0045), NRG3 (p=0.0073) and NRG4 (p=0.026) were significantly related to survival in recurrent gliomas (all WHO grade, Figures S1, S3, S4), and NRG2 (p=0.031) and NRG3 (p<0.0001) were significantly related to survival in primary gliomas (all WHO grades, Figures S2, 3).