The high NRG3 expression is significantly associated with a good prognosis (p=7.8e-05, HR=2.088, 95%CI: 1.449, 3.008 for OS, and p=0.00851, HR=1.47, 95%CI: 1.103, 1.958 for PFS) for patients with LGG, but the high NRG1 expression is significantly associated with a poor prognosis (p=0.025, HR=0.664, 95%CI: 0.464, 0.95 for OS, and p=0.00652, HR=0.604, 95%CI: 0.42, 0.869 for PFS) for patients with GBM. This evidence concerns the gene NRG1 and glioblastoma.