To further confirm the prognostic value of different NRG family members signature in LGG and GBM, both univariate and multivariate Cox regression analyses were performed, showing that only NRG3 is independently associated with the OS of LGG patients (Figure 11A), and only NRG1 is significantly related to theOS of GBM patients (Figure 11B). This evidence concerns the gene NRG3 and glioblastoma.