The expression level of 17 m6A-related genes in normal, LGG and GBM patients was significantly different, and the expression level of METTL14, WTAP, RBM15, RBM15B, ZC3H13, YTHDC1, YTHDF3, YTHDF1, YTHDF2, IGF2BP2, IGF2BP3, RBMX, HNRNPA2B1 and ALKBH5 in the patients with LGG (P<0.001) and GBM (with P<0.001) were significantly higher than that in the patients of normal group (Figure 8C). This evidence concerns the gene ALKBH5 and glioblastoma.