LILRB2 and colorectal carcinoma: Moreover, there has been evidence that HLA-G upregulates ILT-4 expression in CRC cell lines in an autocrine manner, and HLA-G/ILT-4 engagement enhances CRC cell proliferation, migration, and invasion by the activation of protein kinase B (AKT)/extracellular signal regulated kinase (ERK) signaling (40).