The patients involved in these case reports or case series mainly developed severe uveitis with prolonged disease duration and resistance to topical and systemic corticosteroids, immunosuppressors, TNF-α inhibitors, or other biologics. Resistance to some of the classical drugs and the response to rituximab indirectly suggest that B cells participate in the pathogenesis of non-infectious uveitis in autoantibody-independent ways, particularly in the late phase of diseases. The gene discussed is TNF; the disease is uveitis.