Importantly, nine of the chemokines identified in the 12CK-GES have reported up-regulation by LTBR signaling in mesenchymal-derived stroma through canonical or non-canonical NF-κB signaling, whereas the remaining three are hallmark products of tumor-associated macrophages (TAM), or type-II polarized macrophages (60–64) which themselves are recruited by multiple members of the 12CK-GES (Table 1). Here, LTBR is linked to neoplasm.