Notably, disease-associated microglia in lesion biopsies of patients with histologically confirmed early active MS pathology showed reduced expression of the core signature genes CX3CR1, GPR34, GPR183, P2RY12, P2RY13, and ADGRG1 (15, 26) (Figures 3A, B). Here, P2RY13 is linked to myeloid sarcoma.