In conclusion, we report here that compared to HSV-1 infected non-treated mice, the infected and FGF-1 treated mice showed (i) an overall resistance to disease; (ii) a significant decrease in primary stromal keratitis (days 5, 14, and 21) and blepharitis (days 7 and 14); (iii) a significant decrease in disease duration in herpes reactivation and (iv) a significant decrease in corneal inflammatory macrophage. This evidence concerns the gene FGF1 and blepharitis.