The tumor establishes an immune suppressive environment by the secretion of immune suppressive cytokines and chemokines, by metabolic acidification (6), by the recruitment of immune-regulatory cells, such as regulatory T cells (T regs) and myeloid-derived suppressor cells (MDSCs), by affecting the polarization of macrophages as well as by up-regulation of immunosuppressive proteins including ligands for immune checkpoint (ICP) receptors, such as PD-L1. Here, CD274 is linked to neoplasm.