The expression levels of writers (METTL3 and WTAP) and readers (i.e., IGF2BP3, YTHDF1, HNRNPA2B1 and HNRNPC) were notably higher in ESCC tissues than in normal adjacent tissues (Figure 1B) (P < 0.05). This evidence concerns the gene YTHDF1 and esophageal squamous cell carcinoma.