Furthermore, we also constructed a five-gene prognostic signature consisting of HNRNPC, RBM15, IGF2BP3, METTL16, and KIAA14297 from m6A methylation regulators, and the calculated risk score showed good performance in predicting the prognostic outcome of ESCC patients. This evidence concerns the gene IGF2BP3 and esophageal squamous cell carcinoma.