PADI1 and neoplasm: In hPD-L1-B16-F10 tumor-bearing mice, treatment with 4 mg/kg PDI-1 significantly increased the percentage of CD3+ T cells in the peripheral blood compared with vehicle-treated mice, and there was a similar, albeit not significant, trend in the effects of PDI-1 on the abundance of intratumoral CD3+ T cells (Figure 6C).