H&E staining of hPD-L1-B16-F10 tumors (Figure 4C) and hPD-L1-KLN205 tumors (Figure 5D), showed that PDI-1 treatment caused a marked increase in tumor infiltration by inflammatory cells and necrosis of tumor cells compared with tumors from vehicle-treated mice. The gene discussed is PADI1; the disease is neoplasm.