To determine whether PDI-1 also inhibits tumor-cell-induced cytokine production by activated CD3+ T cells, we collected the culture supernatants after 18 h incubation and performed ELISAs to measure secretion of the cytolytic proteins granzyme B and perforin and the inflammatory cytokines IFN-γ and TNF-α. The gene discussed is PRF1; the disease is neoplasm.