Therefore, we see patients with anti-CASPR2 encephalitis presenting limbic encephalitis (fever, epilepsy, amnesia, sleep disorder, hallucination, psychosis, behavioral disorder), Morvan syndrome (sleep disorder, hallucination, psychosis, behavioral disorder, constipation, tachycardia, hyperhidrosis, paresthetica, weight loss), and peripheral nerve hyperexcitability (paresthetica, fasciculation, limb twitch), which is rarely seen in other encephalitis. This evidence concerns the gene CNTNAP2 and encephalitis.