As shown in Figures 5A, B, PRX3 knockdown aggravated the triggering effect of NLRP3 on pyroptosis (including the increased serum level of LDH and protein levels of GSDMD-N, caspase-1 p20, IL-1β and IL-18) in KCs, which was vastly attenuated by NLRP3-specific siRNA. The gene discussed is IL1B; the disease is dry eye syndrome.