cDC1 number also correlated with disease severity indicating they may play a role in this condition, Second, in interstitial fibrosis associated immune-mediated disease (IgA nephropathy and lupus nephritis), we found that cDC1 number correlated with severity of fibrosis, as well as prognosis in IgA nephropathy, while no such correlation was found in non-immune mediated fibrotic disease (diabetic nephropathy). The gene discussed is MPPE1; the disease is lupus nephritis.