MPPE1 and diabetic kidney disease: The second significant finding in this study is that cDC1 number correlated with the severity of interstitial fibrosis associated with immune-mediated disease (IgA nephropathy and lupus nephritis), but not in non-immune mediated fibrotic disease (diabetic nephropathy), Previous study showed increased numbers of cDC1s and cDC2s in interstitial fibrosis (9).