We conducted this study to provide analysis of the key cDC subsets, cDC1 and cDC2, in a wide range of human kidney diseases including non-glomerular diseases [acute tubular necrosis (ATN), acute interstitial nephritis (AIN)], proliferative GN (IgA nephropathy, lupus nephritis, pauci-immune GN, anti-GBM disease), non-proliferative GN (minimal change disease (MCD), membranous nephropathy) and diabetic nephropathy. This evidence concerns the gene MPPE1 and diabetic kidney disease.