IKZF2 and type 1 diabetes mellitus: As shown in Figures 7A, B, we observe positive correlations between classic monocytes and Treg subsets in both healthy controls (for Helios+ subsets, Spearman r = 0.613, P = 2.87E-06; for Helios− subsets, Spearman r = 0.643, P = 2.68E-06) and T1D individuals (for Helios+ subsets, Spearman r = 0.380, P = 0.0035; for Helios− subsets, Spearman r = 0.307, P = 0.020) (Figures 7C, D).