Meanwhile, a newly published meta-analysis showed that T2DM risk was closely related to the increased levels of inflammatory cytokines such as Tumor necrosis factor-α (TNF-α), Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Interleukin-18 (IL-18), and C-reactive protein (CRP) (4). This evidence concerns the gene IL18 and type 2 diabetes mellitus.