PLOD1 and Follicular Cyst: Absence or abnormal release of hypothalamic gonadotropin-releasing hormone (GnRH) or lack of luteinizing hormone (LH) surge were considered as one of the endocrine reasons to induce a follicular cyst, identified as a target for symptomatic therapies to treat infertility (Medan et al., 2004; Abdalla et al., 2020).