Studies have found that bone marrow stromal cells (BMSCs) of mice with type 2 diabetes oversecrete succinate (an intermediate metabolite in the TCA cycle that participates in regulating the energy supply) that binds to succinate receptor 1 (SUCNR1) of osteoclasts as an extracellular ligand and stimulates osteoclastogenesis in vitro and in vivo without increasing the number of OC precursor cells. This evidence concerns the gene SUCNR1 and type 2 diabetes mellitus.