In contrast, all animals that received direct infusions of islets in greater numbers (19,000; 17,000; 32,000 IEQ/kg, respectively) either into recipients’ livers or under the renal capsule at the day of allogeneic transplantation all went on to require exogeneous insulin and ultimately were sacrificed secondary to complications from hyperglycemia (51). Here, INS is linked to Hyperglycemia.