Total calcium level (normalized by serum albumin concentration) is positively related to the bone mass decline in the non-diabetic group but not in the diabetic group, however, the level of calcium-regulating hormones, PTH and 25(OH)D, had no difference between normal, osteopenia and osteoporosis subgroups in both type 2 diabetic and non-diabetic groups (Table 1). The gene discussed is PTH; the disease is Osteopenia.