In stroke models using diabetic rats, hyperglycemia increases neutrophil adhesion and transmigration, and also increases expression of TNF, IL-1β, E-selectin, soluble intercellular adhesion molecules (sICAMs), endothelial NO synthase (eNOS) and inducible nitric oxide synthase (iNOS) (54, 71). This evidence concerns the gene NOS2 and stroke disorder.