P2RX7 and Alzheimer disease: When interrogating the microglia purinergic transcriptomic data from AD patients and AD mouse models we summarized here, a microglial response pattern emerges, in which Adora1 and P2rx4 are upregulated and Adora3, P2rx7, P2ry6, P2ry12, and P2ry13 downregulated (Figure 3).