The most common ones are the sporadic forms of Alzheimer's disease (AD; TAU/amyloid-β (Aβ) aggregates), Parkinson's disease (PD; α-SYN aggregates), amyotrophic lateral sclerosis (ALS; TAR DNA binding protein 43 (TDP-43)/FUS RNA binding protein (FUS) aggregates), Lewy body dementia (α-SYN aggregates) and frontotemporal lobar degeneration (FTLD; TAU/TDP-43/FUS aggregates) (2). The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.