While a considerable upregulation was also noted for CSF CHIT1 levels, the effect did not reach significance (ALS = 14.56 ng/ml, [−6.02, 35.14] vs. NDC = 2.65 ng/ml [−0.31, 5.62], U = 6, p = 0.017). Here, CHIT1 is linked to amyotrophic lateral sclerosis.