Conversely, CSF CHI3L1 levels were significantly upregulated within the ALS group relative to the NDC group (ALS = 398.4 ng/ml, [256, 540.8] vs. NDC = 218.9 ng/ml [65.25, 372.5], U = 6, p = 0.017). Here, CHI3L1 is linked to amyotrophic lateral sclerosis.