Uremic toxins, especially those of low molecular weight, bind to proteins after being absorbed, mainly to Human Serum Albumin (HSA), and are not always effectively removed from the body of CKD patients through peritoneal dialysis or hemodialysis (Ito et al., 2010; Watanabe et al., 2013; Vanholder et al., 2014). This evidence concerns the gene ALB and chronic kidney disease.