Arid2-IR shares a similar mechanism with Ptprd-IR that overexpression of Arid2-IR may promote TGF-β1-, IL-1β-induced NF-κB-driven inflammation without affecting TGF-β/Smad3-mediated renal fibrosis (Zhou et al., 2015a). The gene discussed is ARID2; the disease is renal fibrosis.