Knockdown of TCONS_00088786 may inhibit the mRNA expression profile of the gene Acta1, Col1a1, and Col3a1, while knockdown of TCONS_01496394 decreases the mRNA expression of Ctgf and Fn1, suggesting their potential in promoting renal fibrosis (Sun et al., 2017). This evidence concerns the gene CCN2 and renal fibrosis.