NFE2L2 and cardiomyopathy: To determine a causative role of autophagy in the regulation of cardiomyopathy and Nrf2-mediated dichotomy in PO hearts, we determined the impact of cardiac specific autophagy inhibition via CR-Atg5KO on TAC-induced cardiac remodeling and dysfunction as well as Nrf2-mediated dichotomy (Qin et al., 2016) in adult mice.