In this regard, we lately demonstrated that PO-induced cardiomyopathy and heart failure are dramatically ameliorated by enhancing myocardial autophagy via cardiomyocyte-restricted (CR)-autophagy related 7 (Atg7) transgenic overexpression (Qi et al., 2020), providing critical evidence to support adaptive nature of autophagy activation in PO hearts. The gene discussed is ATG7; the disease is heart failure.