Under this respect, it is worth noting that beneficial effects of enhancing ACE-2 have been demonstrated in a single patient with severe COVID-19 (a trial is ongoing) who was given human recombinant soluble ACE2 with the double rationale of blocking SARS-CoV2 spike proteins and of lowering Ang II at the same time enhancing Ang-(1-7) (Zoufaly et al., 2020). This evidence concerns the gene ACE2 and COVID-19.