When we compared the effects of the AADs between the wild-type and PITX2+/− deficiency models (Table 3), the APD90 changes were similar (p = 0.223, effect size = 0.109), but the reductions in the CV (p = 0.033, effect size = 0.202), peak DF (p < 0.001, effect size = 0.517), and PS number (p < 0.001, effect size = 0.712) and AFCL prolongation (p = 0.001, effect size = 0.529) and change of Smax (p < 0.001, effect size = 0.439) were more significant in the PITX2+/− deficiency model than in the wild-type AF model. The gene discussed is PITX2; the disease is atrial fibrillation.