In concordance with findings in brain of subjects with schizophrenia, previous works confirmed that this MIA model promotes the accumulation of pro-inflammatory mediators such as different cytokines, as well as intracellular inflammatory and oxido/nitrosative mediators such as the transcription factor NFkB or the inducible nitric oxide synthase (iNOS) (Song et al., 2011; Volk et al., 2015; MacDowell et al., 2017; Goh et al., 2020). The gene discussed is NOS2; the disease is schizophrenia.