For example, the level of serum IL-6 in DN patients is higher than that without DN patients (Taslipinar et al., 2011) and the risk of DN in type 2 diabetes mellitus (T2DM) patients with high IL-6 gene polymorphism is increased (Papaoikonomou et al., 2013). The gene discussed is IL6; the disease is type 2 diabetes mellitus.