Furthermore, Epithelial-mesenchymal transition (EMT) and Endothelial-mesenchymal transition (EndMT) caused by the higher levels of IL-6, IL-1β and TGF-β are the key mesenchymal inducers that play important roles in the renal fibrosis (Humphreys, 2018; Weng et al., 2019; Zhang et al., 2019). The gene discussed is IL1B; the disease is renal fibrosis.