Relevance to IBD is suggested by studies in experimental colitis models (Sun et al., 2019; Colgan et al., 2020; Yin et al., 2020), and cell lines (Muenchau et al., 2019; Vissenaekens et al., 2019), which indicate a protective stabilization of HIF1α, attenuating mucosal inflammation and promoting barrier formation. This evidence concerns the gene HIF1A and colitis.