Exploring the gene lists (GEO, GSE172404) we found that e.g., the highly relevant IBD-cytokines IL23, IL1Α and IL1Β were higher expressed in colonoids from UC compared to healthy control colonoids upon TNF and TNF/IL17 treatment, particularly in 2% O2 (Figure 5B). The gene discussed is IL17A; the disease is inflammatory bowel disease.