Figures 5B,C present isolated LSECs phagocytosed Dil-Ac-LDL and expressed CD31, both of which are features of LSECs. Primary LSECs were also isolated from liver fibrosis model mice prompted by CCl4, which expressed considerably higher SphK1 than that in the Wild mice (p < 0.01) (Figure 5D). Here, SPHK1 is linked to Hepatic fibrosis.