Upregulation of CD73 has also been found in glioma (Quezada et al., 2013; Xu et al., 2013), while in a model of multiple sclerosis, upregulation of CD73 and CD39 has been reported in reactive astrocytes and in microglia, respectively (Lavrnja et al., 2015; Jakovljevic et al., 2019). This evidence concerns the gene NT5E and central nervous system cancer.