Singgih et al. (2021) have recently reported the expression of orthologues of the NT5C2 family in the brain of Drosophila melanogaster and that the neuronal knockdown of two of them resulted in impaired habituation learning. NT5DC2 has also been associated with cognitive ability, bipolar disorder and schizophrenia (Watanabe et al., 2019) while the expression level of Nt5dc3, has been positively correlated with reversal learning performance in mice (Laughlin et al., 2011). The gene discussed is NT5C2; the disease is schizophrenia.