In addition, it has been reported that dysregulation of the AMPK signaling in motor neurons is an early and common event in ALS (Perera and Turner, 2016) and that psychiatric disorders are also associated with dysregulation of AMPK signaling (Perera and Turner, 2016; Rosso et al., 2016). This evidence concerns the gene PRKAA2 and amyotrophic lateral sclerosis.