It would be valuable to obtain information on the levels of expression and activity of NT5C2 and the concentration of AMP and ATP in HSP patients, since alterations of their ratio affect AMPK activity, and a continous activation of this enzyme could result in abnormal functioning and development of the nervous system (Pesi et al., 2000; Garcia-Gil et al., 2003; Williams et al., 2011; Domise et al., 2019) (see section AMPK). This evidence concerns the gene PRKAA1 and hereditary spastic paraplegia.