Mutations of ADK or modification of ADK levels have been associated with several diseases (Garcia-Gil et al., 2018), such as stroke (Shen et al., 2011), Rasmussen encephalitis (Luan et al., 2013), focal cortical dysplasia (Luan et al., 2015), epilepsy (Boison, 2016) and gliomas (de Groot et al., 2012; Huang et al., 2015), as well as in cognition deficits (Bjursell et al., 2011; Singer et al., 2012; Sandau et al., 2016; Shakiba et al., 2016; Staufner et al., 2016; Osborne et al., 2018; Kuptanon et al., 2019). Here, ADK is linked to central nervous system cancer.