Deficiency of ADA2 arises from mutations affecting catalytic activity, protein dimerization, and secretion of ADA2 and causes vasculopathy and inflammation in many organs and/or hemorrhagic stroke (Navon Elkan et al., 2014; Zhou et al., 2014; Meyts and Aksentijevich, 2018; Gibson et al., 2019; Sahin et al., 2020; Zervou et al., 2020; Sozeri et al., 2021). This evidence concerns the gene ADA2 and vascular disorder.