NT5E and amyotrophic lateral sclerosis: In reactive astrocytes, increased CD73 gene expression or increased CD73 activity was reported in ALS (Gandelman et al., 2010), epilepsy (Bonan et al., 2000; Bonan, 2012), ischemia (Braun et al., 1998) and traumatic brain injury (Nedeljkovic et al., 2006; Bjelobaba et al., 2011).