NT5C2 and hereditary spastic paraplegia: NT5C1 has been associated to some autoimmune diseases (Rietveld et al., 2018), while an association has been reported between NT5C2 expression and psychiatric and psychomotor disorders including schizophrenia (Cross-Disorder Group of the Psychiatric Genomics Consortium, 2013; Duarte et al., 2016; Duarte et al., 2019) and hereditary spastic paraplegias (HSP) (Garcia-Gil et al., 2018; Camici et al., 2020).