However, some studies have found that inhibiting GLS does not always bring about desired results, especially in cancers with poor vascularization and limited ability of extracting circulating Gln, where they depend on the increased expression of GS to synthesize de novo Gln autonomously (Tardito et al., 2015; Bott A. J. et al., 2019). The gene discussed is GLUL; the disease is cancer.