To test the inhibitory effect of Almonertinib on the proliferation of NSCLC cells, we selected EGFR wild-type (WT) cell line A549 and T790m mutant cell line H1975 to observe the effects of different concentrations of Almonertinib (2, 4, 8, and16 μM) on cell viability of two cell lines after 24, 48, and 72 h. This evidence concerns the gene EGFR and non-small cell lung carcinoma.