Similar findings were reported in the Hyperinsulinemia: the Outcome of its Metabolic Effects (HOME) randomized trial; in this study, treatment with metformin improved glycemic control and reduced macrovascular complications (MI, stroke, peripheral vascular disease) in diabetic patients already on insulin therapy on a 4.3 years clinical follow-up (Kooy et al., 2009). The gene discussed is INS; the disease is stroke disorder.