Similar results emerge from the Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction (DIGAMI) Study, which demonstrated a significant 25% reduction in mortality (at 3.4 years of follow-up) among patients with diabetes and MI who underwent an initial 24h glucose-insulin infusion followed by an intensified insulin therapy (Malmberg, 1997). This evidence concerns the gene INS and diabetes mellitus.