Consistently, a significant increase in the ovarian protein levels of TLR4, as well as the relative expression ratios of p-PI3K to PI3K, p-Akt to Akt, and p-p65 to p65 was observed in the PCOS rats as compared to the normal group, while SGD treatment reversed the expressions (Figures 6C,D). Here, AKT1 is linked to polycystic ovary syndrome.