IL18 and polycystic ovary syndrome: Typically, females with PCOS are predisposed to have elevated levels of pro-inflammatory cytokines [e.g., interleukins (IL)-6 and IL-18] as well as the declined levels anti-inflammatory cytokines (e.g. IL-10 and IL-22) (Qi et al., 2019; Wang et al., 2020a).