It has neuroprotective activity by inhibiting dopaminergic neuron loss, aggregation of α-syn protein, and dopamine level depletion. It reduced apoptosis by decreasing the expression level of egg-laying abnormal-1, an apoptosis modulator. Protein aggregation and misfolding causing the production of inclusion bodies make an important contribution to the pathogenesis of PD. It may prevent pathogenesis by enhancing proteolysis by a somatic proteasome activity intervened by increasing the expression level of rpn-5, a proteasome regulatory subunit. Here, PSMD12 is linked to Parkinson disease.