IL-35 is considered to activate several signal transduction pathways, including JAK-STAT (Janus Kinase-signal transducer and activator of transcription), Ang2-Tie2 (TEK Tyrosine kinase, Endothelial), and Wnt-β-catenin signaling pathways which regulated the procedure of RA. This evidence concerns the gene TEK and rheumatoid arthritis.