EGFR and ovarian carcinoma: However, establishing a causal link between elevated ADAM17, EGFR ligands and nociception and pain sensitization requires additional research, as some ADAM substrates may transactivate EGFR, including IL-6, which in ovarian cancer, may exhibit crosstalk with EGFR in both its membrane-bound and soluble state (Colomiere et al., 2009).