socioeconomic status, diabetes mellitus, ischemic heart disease, myocardial infarction, heart failure, cerebrovascular disease, chronic kidney disease, chronic liver disease, chronic lung disease, depression, Charlson’s index, diuretics, human insulin, statin, fibrates, aspirin, hormone replacement therapy, number of lipid measurements, number of mammography, number of outpatient visits, number of hospitalizations, and length of hospital admission more than 7 days matched on age (within 5 years) and follow-up duration. This evidence concerns the gene INS and chronic kidney disease.