Neutrophil infiltration with high intrapulmonary protease levels (e.g., neutrophil elastase) and excess of proinflammatory cytokines, such as interleukin 6 (IL-6) are associated with “hyperinflammation” in the CF lung leading to the progressive damage of the bronchial tree (Nixon et al., 1998; Cantin et al., 2015). This evidence concerns the gene IL6 and cystic fibrosis.