CFTR and cystic fibrosis: In CF, the cystic fibrosis transmembrane conductance regulator (Cftr) knockout (KO) mouse has provided important insight into avenues for immune cell based interventions with better understanding of the roles epithelial cells, macrophages and T-cells (Hodges et al., 2011; Bonfield et al., 2012; Ng et al., 2014).