It is widely known that NMDARs activate primary signaling cascades including PI3 kinase-Akt-GSK-3β and Ras-MAPK kinase (MEK)-MAPK signaling pathways, both of which are involved in the pathogenesis of schizophrenia and the therapeutic mechanisms of antipsychotic agents (Seo et al., 2007). The gene discussed is AKT1; the disease is schizophrenia.