RHOA and neurodegenerative disease: Although it was found that CNF1 treatment led to prolonged activation of Rac1 in comparison to that of RhoA in mice and rats, similar results obtained point to the potential complexity of how activation or inactivation of Rho GTPases may positively modify neurodegenerative diseases (Diana et al., 2007; Cerri et al., 2011; Aguilar et al., 2017b).