TARDBP and amyotrophic lateral sclerosis: ALS is marked by degeneration of motor neurons in the motor cortex, brain stem and spinal cord with most cases of familiar ALS arising from genetic mutations such as TDP-43, chromosome 9 open reading frame 72 (C9ORF72), superoxide dismutase (SOD1), fused in sarcoma (FUS) and ALS2 (Ghasemi and Brown, 2018).