Interestingly, the intranuclear inclusions in NIID patients partially resemble those of FXTAS, which are both ubiquitinated and immunoreactive for p62 (Mori et al., 2012), supporting our prediction that NIID and FXTAS could share overlapping mechanisms of neurodegeneration characterized by formation of the neural inclusions. This evidence concerns the gene KHDRBS1 and neuronal intranuclear inclusion disease.