RAN translation has been detected in many repeat expansion disorders (e.g., Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (ALS-FTD) with expanded GGGGCC repeats, Spinocerebellar Ataxia Type 8 (SCA8) with CAG repeats, and FXTAS with CGG repeats (Zu et al., 2011; Sellier et al., 2013), suggesting an essential role of the shared RAN translation mechanism in disorders caused by various repeat expansion. This evidence concerns the gene RAN and amyotrophic lateral sclerosis.