Interestingly, apart from PD, decreased levels of parkin have been found in motor neurons with TDP-43 inclusions derived from the spinal cord of sporadic ALS patients (Lagier-Tourenne et al., 2012) and cellular and animal models of TDP-43 proteinopathy (Sun et al., 2018). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.