PRKN and neuroblastoma: Sun et al. (2018) demonstrated parkin downregulation upon overexpression of wild type TDP-43-HA for 48 h in HEK293T cells, and in primary mouse neurons. In addition, knock-in of wild-type human TDP-43 in the Drosophila model caused a significant reduction of the endogenous parkin protein and mRNA. In contrast, other groups demonstrated parkin upregulation upon TDP-43 overexpression in HEK293T and M17 neuroblastoma cells, respectively (Hebron et al., 2013; Davis et al., 2018; Supplementary Table 3).