According to the reportedcleavage sites on human tau in AD brain (Wang et al., 2010; Zhang et al., 2014), we deleted the first 50, 150 or 230 amino acids(a.a.)and the last 20 or 50 a.a. of the longest human tau isoformtau441, examined the pathological activities of each truncatedisoforms, and found that deletion of the first 150 and the last 50 a.a. of tau enhanced its site-specific phosphorylation, self-aggregation, and captured and seeded aggregation by ADO-Tau (Gu et al., 2020). Here, MAPT is linked to Alzheimer disease.