Intrahippocampal injection of AD P-tau (the same as AD O-tau mentioned in this work) induced tau pathology first at the injection sites, and then to the anatomically connected regions in mouse brain, mimicking the propagation of tau pathology observed in AD patients (Lasagna-Reeves et al., 2012a; Hu et al., 2016). The gene discussed is MAPT; the disease is Alzheimer disease.