Intrahippocampal injection of tau aggregates isolated from AD patients or produced in vitro successfully induced tau hyperphosphorylation and NFT formation at the injection sites and anatomically related regions in rodent brains, showing a similar stereotypical propagation of tau pathology as observed in AD brain (Clavaguera et al., 2009; Boluda et al., 2015; Takeda et al., 2015; Hu et al., 2016; Miao et al., 2019). Here, MAPT is linked to Alzheimer disease.