GABA is the major inhibitory transmitter in the adult mammalian brain, and AD patients have increased GABA levels in their cerebrospinal fluid (Samakashvili et al., 2011) and antagonists of GABAA receptors improve hippocampal LTP and memory in an AD (APP/PS1) mouse model (Yoshiike et al., 2008). Here, APP is linked to Alzheimer disease.