ADORA2A and Alzheimer disease: Accordingly, the antagonism of A2AR has been shown to confer neuroprotection in several injurious and pathological brain conditions and can recover memory deficits in animal models of AD, which prompts A2AR as a therapeutic target for this disease (Arendash et al., 2006; Dall’lgna et al., 2007; Canas et al., 2009; Laurent et al., 2016; Viana da Silva et al., 2016; Silva et al., 2018).