BEST1 and Alzheimer disease: In line with these findings, it was reported that hippocampal reactive astrocytes of different AD mouse models (APP/PS1 and 5xFAD) excessively produce GABA and release GABA abundantly through bestrophin 1 (Best1), a channel that in non-reactive astrocyte mediates the release of glutamate (Jo et al., 2014).