ADORA2A and Cognitive impairment: All these findings reporting that the blockade of A2AR prevents synaptic dysfunction and cognitive deficits, mainly memory loss, in conditions of AD, support that the modulation of synaptic function may constitute an interesting strategy to improve memory dysfunction related to neurodegenerative processes (Coleman et al., 2004; Wishart et al., 2006; Canas et al., 2018).