MOG and myeloid sarcoma: Kerschensteiner et al. (2004) created a targeted EAE model by injecting a cytokine solution in the spinal cord of rats sensitized with recombinant myelin oligodendrocyte glycoprotein (MOG; Ineichen et al., 2017). Even though lesions reflected key features of MS pathology and could be reliably targeted to specific white matter tracts in the spinal cord (Kerschensteiner et al., 2004), this model is invasive and requires spinal cord surgery.